6E0B

Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1

Summary for 6E0B

• Entry DOI: 10.2210/pdb6e0b/pdb
• Related: 3I65 3I68 3I6R
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm1, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 1
• Total formula weight: 46825.39

Authors

Tomchick, D.R.,Phillips, M.A.,Deng, X. (deposition date: 2018-07-06, release date: 2018-11-14, Last modification date: 2023-10-11)

• Primary citation: White, J.,Dhingra, S.K.,Deng, X.,El Mazouni, F.,Lee, M.C.S.,Afanador, G.A.,Lawong, A.,Tomchick, D.R.,Ng, C.L.,Bath, J.,Rathod, P.K.,Fidock, D.A.,Phillips, M.A.; Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.; ACS Infect Dis, 5:90-101, 2019; PubMed: 30375858; DOI: 10.1021/acsinfecdis.8b00211

Experimental method

X-RAY DIFFRACTION (2.099 Å)