6DRS

Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor

Summary for 6DRS

• Entry DOI: 10.2210/pdb6drs/pdb
• Descriptor: Dihydrofolate reductase, putative, SULFATE ION, 3-{[(3R)-7,9-diamino-3-methyl-2,3-dihydrofuro[2,3-f]quinazolin-4-yl]oxy}benzonitrile, ... (5 entities in total)
• Functional Keywords: antifolate, dhfr, antifungal protein, antifungal protein-inhibitor complex, antifungal protein/inhibitor
• Biological source: Aspergillus flavus
• Total number of polymer chains: 1
• Total formula weight: 29551.11

Authors

Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W. (deposition date: 2018-06-12, release date: 2019-06-19, Last modification date: 2023-10-11)

• Primary citation: Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W.; Prospecting for broad-spectrum inhibitors of fungal dihydrofolate reductase using a structure guided approach.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.997 Å)