Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 301 |
Chain | Residue |
A | GLY134 |
A | LEU135 |
A | GLU136 |
A | THR164 |
A | NAP307 |
A | HOH431 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 302 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 303 |
Chain | Residue |
A | HOH410 |
A | HOH439 |
A | ARG50 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 304 |
Chain | Residue |
A | GLY78 |
A | LYS79 |
A | LYS103 |
A | HOH419 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 305 |
Chain | Residue |
A | GLY55 |
A | THR56 |
A | THR57 |
A | ILE126 |
A | GLY149 |
A | HOH454 |
site_id | AC6 |
Number of Residues | 13 |
Details | binding site for residue H8A A 306 |
Chain | Residue |
A | ILE10 |
A | VAL11 |
A | ALA12 |
A | ASP40 |
A | MET41 |
A | PHE44 |
A | THR66 |
A | ARG80 |
A | ILE156 |
A | TYR162 |
A | THR179 |
A | NAP307 |
A | HOH461 |
site_id | AC7 |
Number of Residues | 31 |
Details | binding site for residue NAP A 307 |
Chain | Residue |
A | VAL11 |
A | ALA12 |
A | ILE26 |
A | GLY27 |
A | GLY30 |
A | THR31 |
A | LEU32 |
A | GLY63 |
A | ARG64 |
A | LYS65 |
A | THR66 |
A | VAL85 |
A | THR86 |
A | ARG87 |
A | LYS121 |
A | SER133 |
A | ILE156 |
A | GLY158 |
A | ALA159 |
A | GLU160 |
A | ILE161 |
A | TYR162 |
A | SO4301 |
A | H8A306 |
A | HOH412 |
A | HOH420 |
A | HOH446 |
A | HOH448 |
A | HOH453 |
A | HOH474 |
A | HOH490 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 24 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGlngtLPWprikaDmsfFarvT |
Chain | Residue | Details |
A | GLY25-THR48 | |