6DRS
Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase, putative | polymer | 256 | 27994.0 | 1 | UniProt (B8NBN5) Pfam (PF00186) | Aspergillus flavus | |
| 2 | B, C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | G (A) | 3-{[(3R)-7,9-diamino-3-methyl-2,3-dihydrofuro[2,3-f]quinazolin-4-yl]oxy}benzonitrile | non-polymer | 333.3 | 1 | Chemie (H8A) | |||
| 4 | H (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 5 | I (A) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 3 - 248 (UniProt: B8NBN5)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Leu 249 | - | expression tag |
| Glu 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
| His 256 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27994.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1557.1 | |
| All* | Total formula weight | 29551.1 |
