6DRS

Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dihydrofolate reductase, putative	polymer	256	27994.0	1	UniProt (B8NBN5) Pfam (PF00186) In PDB	Aspergillus flavus
2	A	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	A	3-{[(3R)-7,9-diamino-3-methyl-2,3-dihydrofuro[2,3-f]quinazolin-4-yl]oxy}benzonitrile	non-polymer		333.3	1	Chemie (H8A)
4	A	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	1	Chemie (NAP)
5		water	water		18.0	160	Chemie (HOH)

Sequence modifications

A: 3 - 248 (UniProt: B8NBN5)

PDB	External Database	Details
Met 1	-	expression tag
Ala 2	-	expression tag
Leu 249	-	expression tag
Glu 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
His 256	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27994.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1557.1
All*	Total formula weight	29551.1

*Water molecules are not included.