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6DIF

Wild-type HIV-1 protease in complex with tipranavir

Summary for 6DIF
Entry DOI10.2210/pdb6dif/pdb
Related2IEN 6DIL 6DJ1 6DJ2
DescriptorHIV-1 protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsantiviral agents, protein-inhibitor structures, hiv drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22489.65
Authors
Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (deposition date: 2018-05-23, release date: 2018-10-17, Last modification date: 2023-10-11)
Primary citationWong-Sam, A.,Wang, Y.F.,Zhang, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.
Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.
ACS Omega, 3:12132-12140, 2018
Cited by
PubMed: 30288468
DOI: 10.1021/acsomega.8b01683
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.2 Å)
Structure validation

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