6DIF
Wild-type HIV-1 protease in complex with tipranavir
Summary for 6DIF
Entry DOI | 10.2210/pdb6dif/pdb |
Related | 2IEN 6DIL 6DJ1 6DJ2 |
Descriptor | HIV-1 protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | antiviral agents, protein-inhibitor structures, hiv drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22489.65 |
Authors | Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (deposition date: 2018-05-23, release date: 2018-10-17, Last modification date: 2023-10-11) |
Primary citation | Wong-Sam, A.,Wang, Y.F.,Zhang, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3:12132-12140, 2018 Cited by PubMed: 30288468DOI: 10.1021/acsomega.8b01683 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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