6D94

Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1

6D94 の概要

• エントリーDOI: 10.2210/pdb6d94/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, Mediator of RNA polymerase II transcription subunit 1, (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, super agonist, ligand binding domain, coactivator, med1, dna binding protein, dna binding protein-agonist complex, dna binding protein/agonist
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37263.03

構造登録者

Mou, T.C.,Chrisman, I.M.,Hughes, T.S.,Sprang, S.R. (登録日: 2018-04-27, 公開日: 2019-05-01, 最終更新日: 2023-10-25)

• 主引用文献: Nemetchek, M.D.,Chrisman, I.M.,Rayl, M.L.,Voss, A.H.,Hughes, T.S.; A structural mechanism of nuclear receptor biased agonism.; Proc.Natl.Acad.Sci.USA, 119:e2215333119-e2215333119, 2022; PubMed: 36469765; DOI: 10.1073/pnas.2215333119

実験手法

X-RAY DIFFRACTION (1.9 Å)