6D06

Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base

Summary for 6D06

• Entry DOI: 10.2210/pdb6d06/pdb
• Descriptor: Double-stranded RNA-specific editase 1, RNA (5'-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3'), RNA (5'-R(*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*NP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: adenosine deaminase, rna editing, hydrolase, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 106171.59

Authors

Matthews, M.M.,Fisher, A.J.,Beal, P.A. (deposition date: 2018-04-10, release date: 2019-02-20, Last modification date: 2023-10-04)

• Primary citation: Monteleone, L.R.,Matthews, M.M.,Palumbo, C.M.,Thomas, J.M.,Zheng, Y.,Chiang, Y.,Fisher, A.J.,Beal, P.A.; A Bump-Hole Approach for Directed RNA Editing.; Cell Chem Biol, 26:269-, 2019; PubMed: 30581135; DOI: 10.1016/j.chembiol.2018.10.025

Experimental method

X-RAY DIFFRACTION (2.55 Å)