6CZE
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with inosine triphosphate (ITP) - promiscuous binding mode with disordered nucleoside
Summary for 6CZE
| Entry DOI | 10.2210/pdb6cze/pdb |
| Related | 3FGN 3FMF 3FMI 3FPA 4WOP 6CVE 6CVF 6CVU 6CVV 6CZB 6CZC 6CZD |
| Descriptor | ATP-dependent dethiobiotin synthetase BioD, INOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | enzyme, synthetase, nucleotide triphosphate binding, transferase |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 4 |
| Total formula weight | 96025.54 |
| Authors | Thompson, A.P.,Wegener, K.L.,Bruning, J.B.,Polyak, S.W. (deposition date: 2018-04-09, release date: 2018-11-21, Last modification date: 2024-03-13) |
| Primary citation | Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Abell, A.D.,Booker, G.W.,Bruning, J.B.,Polyak, S.W. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11):10774-10783, 2018 Cited by DOI: 10.1021/acscatal.8b03475PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report
