6CZB

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with uridine triphosphate (UTP) - promiscuous binding mode with disordered nucleoside

Summary for 6CZB

Entry DOI	10.2210/pdb6czb/pdb
Related	3FGN 3FMF 3FMI 3FPA 4WOP 6CVE 6CVF 6CVU 6CVV 6CZC 6CZD 6CZE
Descriptor	ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	enzyme, synthetase, nucleotide triphosphate binding, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	95929.44
Authors	Thompson, A.P.,Wegener, K.L.,Bruning, J.B.,Polyak, S.W. (deposition date: 2018-04-09, release date: 2018-11-21, Last modification date: 2024-03-13)
Primary citation	Thompson, A.P.,Salaemae, W.,Pederick, J.L.,Abell, A.D.,Booker, G.W.,Bruning, J.B.,Polyak, S.W. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11):10774-10783, 2018 Cited by DOI: 10.1021/acscatal.8b03475 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation