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6CZ3

Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone

Summary for 6CZ3
Entry DOI10.2210/pdb6cz3/pdb
DescriptorProtein-tyrosine kinase 6, (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, ACETATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight31161.84
Authors
Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (deposition date: 2018-04-07, release date: 2018-06-20, Last modification date: 2024-03-13)
Primary citationQiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S.
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
PLoS ONE, 13:e0198374-e0198374, 2018
Cited by
PubMed: 29879184
DOI: 10.1371/journal.pone.0198374
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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