6CZ3

Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone

Summary for 6CZ3

DescriptorProtein-tyrosine kinase 6, (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, ACETATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight31161.84
Authors
Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (deposition date: 2018-04-07, release date: 2018-06-20)
Primary citation
Qiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S.
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
PLoS ONE, 13:e0198374-e0198374, 2018
PubMed: 29879184 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0198374
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.209801.3%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29