6CZ3
Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein-tyrosine kinase 6 | polymer | 264 | 30248.9 | 1 | UniProt (Q13882) Pfam (PF07714) In PDB | Homo sapiens (Human) | Breast tumor kinase,Tyrosine-protein kinase BRK |
| 2 | A | (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | non-polymer | 421.4 | 1 | Chemie (FLJ) | |||
| 3 | A | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
A: 182 - 443 (UniProt: Q13882)
| PDB | External Database | Details |
|---|---|---|
| Gly 180 | - | expression tag |
| Ser 181 | - | expression tag |
| Ala 184 | Trp 184 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30248.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 912.9 | |
| All* | Total formula weight | 31161.8 |
