6CZ3

Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue FLJ A 9001

Chain	Residue
A	ARG195
A	MET267
A	ALA268
A	GLY270
A	LYS282
A	ASP330
A	LEU197
A	VAL205
A	ALA217
A	LYS219
A	LEU248
A	THR264
A	GLU265
A	LEU266

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site_id	AC2
Number of Residues	3
Details	binding site for residue ACT A 9002

Chain	Residue
A	ARG223
A	GLN229
A	K9010

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site_id	AC3
Number of Residues	7
Details	binding site for residue ACT A 9003

Chain	Residue
A	ARG186
A	TRP210
A	LYS211
A	ARG213
A	LYS338
A	GLU339
A	HOH9118

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site_id	AC4
Number of Residues	2
Details	binding site for residue ACT A 9004

Chain	Residue
A	MET231
A	LYS327

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site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 9005

Chain	Residue
A	ARG399
A	ALA402
A	TYR404

---

site_id	AC6
Number of Residues	3
Details	binding site for residue ACT A 9006

Chain	Residue
A	SER360
A	ARG361
A	ASP401

---

site_id	AC7
Number of Residues	2
Details	binding site for residue ACT A 9007

Chain	Residue
A	GLU304
A	ASN307

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site_id	AC8
Number of Residues	4
Details	binding site for residue ACT A 9008

Chain	Residue
A	ASP212
A	TYR351
A	HIS394
A	HOH9173

---

site_id	AC9
Number of Residues	3
Details	binding site for residue K A 9009

Chain	Residue
A	GLU189
A	PHE191
A	THR192

---

site_id	AD1
Number of Residues	3
Details	binding site for residue K A 9010

Chain	Residue
A	ARG223
A	LEU226
A	ACT9002

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGYFGEVFeGlwkdrvq...........VAIK

Chain	Residue	Details
A	LEU197-LYS219

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLAARNILV

Chain	Residue	Details
A	TYR308-VAL320

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP312

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU197

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:27480927, ECO:0000305|PubMed:27993680

Chain	Residue	Details
A	LYS219

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12121988

Chain	Residue	Details
A	TYR342
A	TYR351

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