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6CY4

RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.

Summary for 6CY4
Entry DOI10.2210/pdb6cy4/pdb
Related5VR4
DescriptorRNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3') (2 entities in total)
Functional Keywordsrna, oligonucleotide, modified base
Biological sourcesynthetic construct
Total number of polymer chains8
Total formula weight21196.08
Authors
Harp, J.M.,Egli, M. (deposition date: 2018-04-04, release date: 2018-08-29, Last modification date: 2024-03-13)
Primary citationHarp, J.M.,Guenther, D.C.,Bisbe, A.,Perkins, L.,Matsuda, S.,Bommineni, G.R.,Zlatev, I.,Foster, D.J.,Taneja, N.,Charisse, K.,Maier, M.A.,Rajeev, K.G.,Manoharan, M.,Egli, M.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46:8090-8104, 2018
Cited by
PubMed: 30107495
DOI: 10.1093/nar/gky703
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.851 Å)
Structure validation

217705

건을2024-03-27부터공개중

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