6CXM

Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218

Summary for 6CXM

• Entry DOI: 10.2210/pdb6cxm/pdb
• Related: 5U26
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (4 entities in total)
• Functional Keywords: niaid, national institute of allergy and infectious disease, structural genomics, mycobacterium tuberculosis, mtb, inhibitor, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
• Total number of polymer chains: 2
• Total formula weight: 39153.48

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-04-03, release date: 2018-04-11, Last modification date: 2023-10-04)

• Primary citation: Edwards, T.E.,Abendroth, J.,Lorimer, D.D.,Horanyi, P.S.,Seattle Structural Genomics Center for Infectious Disease; Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)