6CXM
Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 164 | 18472.9 | 2 | UniProt (I7FC10) Pfam (PF00186) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) | |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, F (A, B) | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | non-polymer | 360.4 | 2 | Chemie (MMV) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: I7FC10)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Ala -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36945.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2207.6 | |
| All* | Total formula weight | 39153.5 |
