6CXM

Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dihydrofolate reductase	polymer	164	18472.9	2	UniProt (I7FC10) Pfam (PF00186) In PDB	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
2	A, B	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	A, B	3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid	non-polymer		360.4	2	Chemie (MMV)
4		water	water		18.0	48	Chemie (HOH)

Sequence modifications

A, B: 1 - 156 (UniProt: I7FC10)

PDB	External Database	Details
Met -7	-	initiating methionine
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36945.9
Non-Polymers*	Number of molecules	4
	Total formula weight	2207.6
All*	Total formula weight	39153.5

*Water molecules are not included.