6CXM
Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue NAP A 201 |
| Chain | Residue |
| A | TRP7 |
| A | LEU46 |
| A | THR47 |
| A | VAL66 |
| A | THR67 |
| A | ARG68 |
| A | THR81 |
| A | ILE92 |
| A | GLY93 |
| A | GLY94 |
| A | ALA95 |
| A | ALA8 |
| A | GLN96 |
| A | ILE97 |
| A | MET100 |
| A | MMV202 |
| A | ILE15 |
| A | GLY16 |
| A | ASN19 |
| A | SER20 |
| A | ILE21 |
| A | GLY44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue MMV A 202 |
| Chain | Residue |
| A | ILE6 |
| A | TRP7 |
| A | ASP28 |
| A | LEU29 |
| A | PHE32 |
| A | VAL55 |
| A | LEU58 |
| A | PRO59 |
| A | ARG61 |
| A | ILE92 |
| A | TYR98 |
| A | THR111 |
| A | NAP201 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue NAP B 201 |
| Chain | Residue |
| B | TRP7 |
| B | ALA8 |
| B | ILE15 |
| B | GLY16 |
| B | ASN19 |
| B | SER20 |
| B | ILE21 |
| B | GLY44 |
| B | ARG45 |
| B | LEU46 |
| B | THR47 |
| B | SER50 |
| B | VAL66 |
| B | THR67 |
| B | ARG68 |
| B | THR81 |
| B | ILE92 |
| B | GLY93 |
| B | GLY94 |
| B | ALA95 |
| B | GLN96 |
| B | ILE97 |
| B | MET100 |
| B | MMV202 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue MMV B 202 |
| Chain | Residue |
| B | ILE6 |
| B | TRP7 |
| B | ILE21 |
| B | ASP28 |
| B | PHE32 |
| B | LYS33 |
| B | LEU51 |
| B | ARG61 |
| B | ILE92 |
| B | TYR98 |
| B | NAP201 |
| B | HOH303 |
