6CUU
Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A
Summary for 6CUU
Entry DOI | 10.2210/pdb6cuu/pdb |
Descriptor | DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total) |
Functional Keywords | rna polymerase, kanglemycin a, transcription inhibitor, transcription, transcription-dna-antibiotic complex, transcription/dna/antibiotic |
Biological source | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) More |
Total number of polymer chains | 8 |
Total formula weight | 442899.84 |
Authors | Molodtsov, V.,Murakami, K.S. (deposition date: 2018-03-26, release date: 2018-07-25, Last modification date: 2024-03-13) |
Primary citation | Mosaei, H.,Molodtsov, V.,Kepplinger, B.,Harbottle, J.,Moon, C.W.,Jeeves, R.E.,Ceccaroni, L.,Shin, Y.,Morton-Laing, S.,Marrs, E.C.L.,Wills, C.,Clegg, W.,Yuzenkova, Y.,Perry, J.D.,Bacon, J.,Errington, J.,Allenby, N.E.E.,Hall, M.J.,Murakami, K.S.,Zenkin, N. Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72:263-274.e5, 2018 Cited by PubMed: 30244835DOI: 10.1016/j.molcel.2018.08.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.994 Å) |
Structure validation
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