6CQ2
Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with oligonucleotide MTS2-12 and Magnesium
Summary for 6CQ2
Entry DOI | 10.2210/pdb6cq2/pdb |
Related | 5D5H |
Descriptor | DNA topoisomerase 1, DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3'), MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | mycobacterium tuberculosis, topoisomerase i, co-crystallization, complex with oligonucleotide and magnesium, isomerase, isomerase-dna complex, isomerase/dna |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More |
Total number of polymer chains | 2 |
Total formula weight | 81944.24 |
Authors | Cao, N.,Thirunavukkaraus, A.,Tan, K.,Tse-Dinh, Y.-C. (deposition date: 2018-03-14, release date: 2018-05-30, Last modification date: 2024-03-13) |
Primary citation | Cao, N.,Tan, K.,Annamalai, T.,Joachimiak, A.,Tse-Dinh, Y.C. Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. Nucleic Acids Res., 46:7296-7308, 2018 Cited by PubMed: 29905859DOI: 10.1093/nar/gky492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.004 Å) |
Structure validation
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