6CPM

Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv

Summary for 6CPM

Entry DOI	10.2210/pdb6cpm/pdb
Related	6CRN 6CSI
Descriptor	Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1d, CALCIUM ION, ... (8 entities in total)
Functional Keywords	deubiuqitination, ubv, high-affinity, inhibition, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	99524.44
Authors	Singer, A.U.,Teyra, J.,Boehmelt, G.,Lenter, M.,Sicheri, F.,Sidhu, S.S. (deposition date: 2018-03-13, release date: 2019-01-23, Last modification date: 2024-04-03)
Primary citation	Teyra, J.,Singer, A.U.,Schmitges, F.W.,Jaynes, P.,Kit Leng Lui, S.,Polyak, M.J.,Fodil, N.,Krieger, J.R.,Tong, J.,Schwerdtfeger, C.,Brasher, B.B.,Ceccarelli, D.F.J.,Moffat, J.,Sicheri, F.,Moran, M.F.,Gros, P.,Eichhorn, P.J.A.,Lenter, M.,Boehmelt, G.,Sidhu, S.S. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27:590-, 2019 Cited by PubMed: 30713027 DOI: 10.1016/j.str.2019.01.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.011 Å)

Structure validation