6CPM

Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0016579	biological_process	protein deubiquitination
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA C 701

Chain	Residue
C	ASP548
C	GLN614
C	HOH826
D	ASP548
D	GLN614
D	HOH832

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site_id	AC2
Number of Residues	3
Details	binding site for residue CA C 702

Chain	Residue
C	GLU598
C	HOH879
D	SER616

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site_id	AC3
Number of Residues	3
Details	binding site for residue CA C 703

Chain	Residue
C	PRO311
C	GLN612
C	HOH1008

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 704

Chain	Residue
C	CYS448
C	CYS451
C	CYS499
C	CYS502

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site_id	AC5
Number of Residues	2
Details	binding site for residue NA C 705

Chain	Residue
C	GLU494
C	ASP495

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site_id	AC6
Number of Residues	6
Details	binding site for residue GOL C 706

Chain	Residue
C	PHE442
C	TYR463
C	THR465
C	PHE485
C	HOH835
F	THR48

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO C 707

Chain	Residue
C	GLU450
C	GLU504

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CA D 701

Chain	Residue
D	ASP459
D	HOH835
D	HOH1005
D	HOH1007

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN D 702

Chain	Residue
D	CYS448
D	CYS451
D	CYS499
D	CYS502

---

site_id	AD1
Number of Residues	2
Details	binding site for residue NA D 703

Chain	Residue
D	LYS408
D	ASN425

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL D 704

Chain	Residue
D	PHE442
D	TYR463
D	THR465
D	PHE485
D	HOH809
E	THR48

---

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL D 705

Chain	Residue
D	GLU284
D	VAL593
D	HOH801
D	HOH898

---

site_id	AD4
Number of Residues	7
Details	binding site for residue CA E 101

Chain	Residue
E	GLN31
E	ASP32
E	HOH226
F	GLN31
F	ASP32
F	HOH237
F	HOH245

---

site_id	AD5
Number of Residues	1
Details	binding site for residue NA F 101

Chain	Residue
F	ASP32

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Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ

Chain	Residue	Details
C	GLY290-GLN305

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY

Chain	Residue	Details
C	TYR556-TYR573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01035, ECO:0000305|PubMed:19553310, ECO:0000305|PubMed:21947082, ECO:0000305|PubMed:22344298, ECO:0000305|PubMed:24852371, ECO:0000305|PubMed:27368102, ECO:0000305|PubMed:33093067

Chain	Residue	Details
C	CYS298
D	CYS298

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093

Chain	Residue	Details
C	HIS572
D	HIS572

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8R5H1

Chain	Residue	Details
C	VAL602
D	VAL602

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