6CPM
Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (C, D) | Ubiquitin carboxyl-terminal hydrolase 15 | polymer | 349 | 39753.0 | 2 | UniProt (Q9Y4E8) Pfam (PF00443) | Homo sapiens (Human) | Deubiquitinating enzyme 15,Ubiquitin thioesterase 15,Ubiquitin-specific-processing protease 15,Unph-2,Unph4 |
| 2 | C, D (E, F) | Ubiquitin variant 15.1d | polymer | 86 | 9639.9 | 2 | Homo sapiens | Ubv 15.1d | |
| 3 | E, F, G, L, Q (C, D, E) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 4 | H, M (C, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I, N, R (C, D, F) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 6 | J, O, P (C, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | K (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | S, T, U, V (C, D, E, F) | water | water | 18.0 | 531 | Chemie (HOH) |
Sequence modifications
C, D: 275 - 470 (UniProt: Q9Y4E8)
C, D: 471 - 552 (UniProt: Q9Y4E8)
C, D: 554 - 615 (UniProt: Q9Y4E8)
| PDB | External Database | Details |
|---|---|---|
| Ser 270 | - | expression tag |
| Gly 271 | - | expression tag |
| Ala 272 | - | expression tag |
| Ala 273 | - | expression tag |
| Ala 274 | - | expression tag |
C, D: 554 - 615 (UniProt: Q9Y4E8)
| PDB | External Database | Details |
|---|---|---|
| Gly 553 | - | linker |
| Ser 616 | - | expression tag |
| Ser 617 | - | expression tag |
| Gly 618 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98785.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 738.5 | |
| All* | Total formula weight | 99524.4 |
