6CDU

Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone

Summary for 6CDU

• Entry DOI: 10.2210/pdb6cdu/pdb
• Descriptor: chimeric alpha1GABAA receptor, (3a,5a)-3-Hydroxypregnane-11,20-dione (2 entities in total)
• Functional Keywords: gabaa receptor, anesthetics, alphaxalone, neurosteroids, protein transport
• Biological source: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)); More
• Total number of polymer chains: 10
• Total formula weight: 375578.36

Authors

Chen, Q.,Arjunan, P.,Cohen, A.E.,Xu, Y.,Tang, P. (deposition date: 2018-02-09, release date: 2018-08-22, Last modification date: 2023-10-04)

• Primary citation: Chen, Q.,Wells, M.M.,Arjunan, P.,Tillman, T.S.,Cohen, A.E.,Xu, Y.,Tang, P.; Structural basis of neurosteroid anesthetic action on GABAAreceptors.; Nat Commun, 9:3972-3972, 2018; PubMed: 30266951; DOI: 10.1038/s41467-018-06361-4

Experimental method

X-RAY DIFFRACTION (3.45 Å)