6CDU

Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EY4 A 501

Chain	Residue
A	GLN242
A	VAL243
A	TRP246
A	PRO401
B	ALA305
B	THR306

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EY4 A 502

Chain	Residue
E	GLN242
E	TRP246
E	PRO401
A	ALA305
A	THR306
A	TYR309

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EY4 B 500

Chain	Residue
B	GLN242
B	VAL243
B	TRP246
B	PRO401
C	ALA305
C	THR306

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EY4 D 500

Chain	Residue
C	GLN242
C	VAL243
C	TRP246
C	PRO401
D	ALA305
D	THR306

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EY4 E 500

Chain	Residue
D	GLN242
D	VAL243
D	TRP246
D	PRO401
E	ALA305
E	THR306
E	TYR309

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EY4 F 500

Chain	Residue
F	ALA305
F	THR306
J	GLN242
J	VAL243
J	TRP246
J	PRO401

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EY4 G 501

Chain	Residue
F	GLN242
F	VAL243
F	TRP246
F	PRO401
G	ILE302
G	THR306

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EY4 G 502

Chain	Residue
G	GLN242
G	VAL243
G	TRP246
G	PRO401
H	ALA305
H	THR306

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EY4 H 500

Chain	Residue
H	GLN242
H	VAL243
H	TRP246
H	PRO401
I	ALA305
I	THR306
I	TYR309

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EY4 I 500

Chain	Residue
I	GLN242
I	VAL243
I	TRP246
I	PRO401
J	THR306

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	810
Details	TRANSMEM: Helical => ECO:0000269|PubMed:29950725, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U

Chain	Residue	Details
A	VAL227-LEU247
C	PRO253-ARG274
C	ALA285-THR306
C	LEU395-THR414
D	VAL227-LEU247
D	PRO253-ARG274
D	ALA285-THR306
D	LEU395-THR414
E	VAL227-LEU247
E	PRO253-ARG274
E	ALA285-THR306
A	PRO253-ARG274
E	LEU395-THR414
F	VAL227-LEU247
F	PRO253-ARG274
F	ALA285-THR306
F	LEU395-THR414
G	VAL227-LEU247
G	PRO253-ARG274
G	ALA285-THR306
G	LEU395-THR414
H	VAL227-LEU247
A	ALA285-THR306
H	PRO253-ARG274
H	ALA285-THR306
H	LEU395-THR414
I	VAL227-LEU247
I	PRO253-ARG274
I	ALA285-THR306
I	LEU395-THR414
J	VAL227-LEU247
J	PRO253-ARG274
J	ALA285-THR306
A	LEU395-THR414
J	LEU395-THR414
B	VAL227-LEU247
B	PRO253-ARG274
B	ALA285-THR306
B	LEU395-THR414
C	VAL227-LEU247

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	ASN248-VAL252
J	ASN248-VAL252
B	ASN248-VAL252
C	ASN248-VAL252
D	ASN248-VAL252
E	ASN248-VAL252
F	ASN248-VAL252
G	ASN248-VAL252
H	ASN248-VAL252
I	ASN248-VAL252

---

site_id	SWS_FT_FI3
Number of Residues	90
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN275-THR284
J	ASN275-THR284
B	ASN275-THR284
C	ASN275-THR284
D	ASN275-THR284
E	ASN275-THR284
F	ASN275-THR284
G	ASN275-THR284
H	ASN275-THR284
I	ASN275-THR284

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:30266951

Chain	Residue	Details
A	TRP246
J	TRP246
B	TRP246
C	TRP246
D	TRP246
E	TRP246
F	TRP246
G	TRP246
H	TRP246
I	TRP246

---