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6CBX

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497

Summary for 6CBX
Entry DOI10.2210/pdb6cbx/pdb
DescriptorN-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl )-1H-pyrrol-3-yl]methanone, ... (7 entities in total)
Functional Keywordssmyd2 mtf9975 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol : Q9NRG4
Total number of polymer chains2
Total formula weight101465.34
Authors
Primary citationZENG, H.,DONG, A.,Hutchinson, A.,Seitova, A.,TATLOCK, J.,KUMPF, R.,OWEN, A.,TAYLOR, A.,Casimiro-Garcia, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,BROWN, P.J.,WU, H.,Structural Genomics Consortium (SGC)
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published,
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

217705

数据于2024-03-27公开中

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