6C79

Conformational Changes in a Class A Beta lactamase that Prime it for Catalysis

Summary for 6C79

• Entry DOI: 10.2210/pdb6c79/pdb
• Descriptor: Beta-lactamase Toho-1, (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 28885.40

Authors

Coates, L.,Langan, P.S.,Vandavasi, V.G.,Cooper, S.J.,Weiss, K.L.,Ginell, S.L.,Parks, J.M. (deposition date: 2018-01-22, release date: 2018-03-21, Last modification date: 2024-03-13)

• Primary citation: Langan, P.S.,Vandavasi, V.G.,Cooper, S.J.,Weiss, K.L.,Ginell, S.L.,Parks, J.M.,Coates, L.; Substrate Binding Induces Conformational Changes in a Class A Beta-lactamase That Prime It for Catalysis; Acs Catalysis, 8:2428-2437, 2018; DOI: 10.1021/acscatal.7b04114

Experimental method

X-RAY DIFFRACTION (1.1 Å)