6C5C

Crystal structure of the 3-dehydroquinate synthase (DHQS) domain of Aro1 from Candida albicans SC5314 in complex with NADH

Summary for 6C5C

Entry DOI	10.2210/pdb6c5c/pdb
Descriptor	3-dehydroquinate synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	chorismate biosynthesis, structural genomics, center for structural genomics of infectious diseases, csgid, lyase
Biological source	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Total number of polymer chains	2
Total formula weight	87738.48
Authors	Michalska, K.,Evdokimova, E.,Di Leo, R.,Stogios, P.J.,Savchenko, A.,Joachimiak, A.,Satchell, K.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2018-01-16, release date: 2018-01-24, Last modification date: 2023-10-25)
Primary citation	Stogios, P.J.,Liston, S.D.,Semper, C.,Quade, B.,Michalska, K.,Evdokimova, E.,Ram, S.,Otwinowski, Z.,Borek, D.,Cowen, L.E.,Savchenko, A. Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans. Life Sci Alliance, 5:-, 2022 Cited by PubMed: 35512834 DOI: 10.26508/lsa.202101358 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation