FGFR1 kinase complex with inhibitor SN37116

Summary for 6C1C

Related6C18 6C19 6C1B
DescriptorFibroblast growth factor receptor 1, 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight72068.45
Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-04, release date: 2019-01-16, Last modification date: 2020-01-01)
Primary citation
Yosaatmadja, Y.,Squire, C.J.,Patterson, A.V.,Smaill, J.B.
Understanding the structural requirements for covalent inhibition of FGFR1-3
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27720 1.4% 7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload