6C1C

FGFR1 kinase complex with inhibitor SN37116

Summary for 6C1C

Related6C18 6C19 6C1B
DescriptorFibroblast growth factor receptor 1, 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight72068.45
Authors
Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-04, release date: 2019-01-16)
Primary citation
Yosaatmadja, Y.,Squire, C.J.,Patterson, A.V.,Smaill, J.B.
Understanding the structural requirements for covalent inhibition of FGFR1-3
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27720 1.4% 7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6c1c
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Molmil generated image of 6c1c
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Molmil generated image of 6c1c
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More Biological unit images

Molmil generated image of 6c1c
no rotation
Molmil generated image of 6c1c
rotated about x axis by 90°
Molmil generated image of 6c1c
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6c1c.pdb1.gz [46.25 KB])
Coordinate files for Biological unit (6c1c.pdb2.gz [44.59 KB])
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