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6C1C

FGFR1 kinase complex with inhibitor SN37116

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BFibroblast growth factor receptor 1polymer31135353.62UniProt (P11362)
Pfam (PF07714)
In PDB
Homo sapiens (Human)FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2A, B7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-onenon-polymer632.62Chemie (YY6)
3BSULFATE IONnon-polymer96.11Chemie (SO4)
4waterwater18.054Chemie (HOH)
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Gly 455-expression tag
Ala 456-expression tag
Met 457-expression tag
Ser 458-expression tag
Ala 488Cys 486engineered mutation
Ser 584Cys 582engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70707.2
Non-Polymers*Number of molecules3
Total formula weight1361.2
All*Total formula weight72068.5
*Water molecules are not included.

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PDB entries from 2024-09-04

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