6BX8

Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)

Summary for 6BX8

• Entry DOI: 10.2210/pdb6bx8/pdb
• Related: 6HAR
• Descriptor: Trypsin-3, Tissue factor pathway inhibitor, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 136141.38

Authors

Coban, M.,Sankaran, B.,Cohen, I.,Hockla, A.,Papo, N.,Radisky, E.S. (deposition date: 2017-12-18, release date: 2019-02-06, Last modification date: 2023-10-04)

• Primary citation: Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N.; Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.; J. Biol. Chem., 294:5105-5120, 2019; PubMed: 30700553; DOI: 10.1074/jbc.RA118.007292

Experimental method

X-RAY DIFFRACTION (1.98 Å)