6BPI

Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates

Summary for 6BPI

• Entry DOI: 10.2210/pdb6bpi/pdb
• Related: 6AU2 6AU3
• Descriptor: Histone-lysine N-methyltransferase SETDB1, MLY-SER-THR-E2G, SULFATE ION, ... (6 entities in total)
• Functional Keywords: setdb1 tudor, fragment hits, epigenetics, methyl lysine reader, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q15047
• Total number of polymer chains: 2
• Total formula weight: 26134.98

Authors

MADER, P.,Mendoza-Sanchez, R.,DONG, A.,DOBROVETSKY, E.,IQBAL, A.,CORLESS, V.,TEMPEL, W.,LIEW, S.K.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.B.,SCHAPIRA, M.,VEDADI, M.,BROWN, P.J.,Santhakumar, V.,FRYE, S.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2017-11-23, release date: 2017-12-27)

• Primary citation: MADER, P.,Mendoza-Sanchez, R.,DONG, A.,DOBROVETSKY, E.,IQBAL, A.,CORLESS, V.,TEMPEL, W.,LIEW, S.K.,SMIL, D.,DELA SENA, C.C.,KENNEDY, S.,DIAZ, D.B.,SCHAPIRA, M.,VEDADI, M.,BROWN, P.J.,Santhakumar, V.,FRYE, S.,Bountra, C.,Edwards, A.M.,YUDIN, A.K.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC); Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates; to be published,

Experimental method

X-RAY DIFFRACTION (1.64 Å)