6BKD

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3D

Summary for 6BKD

• Entry DOI: 10.2210/pdb6bkd/pdb
• Descriptor: Polyprotein, Fab AR3D heavy chain, Fab AR3D light chain, ... (4 entities in total)
• Functional Keywords: hepatitis c virus, hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system
• Biological source: Recombinant Hepatitis C virus HK6a/JFH-1; More
• Total number of polymer chains: 3
• Total formula weight: 68637.90

Authors

Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2017-11-08, release date: 2018-12-26, Last modification date: 2023-10-04)

• Primary citation: Tzarum, N.,Giang, E.,Kong, L.,He, L.,Prentoe, J.,Augestad, E.,Hua, Y.,Castillo, S.,Lauer, G.M.,Bukh, J.,Zhu, J.,Wilson, I.A.,Law, M.; Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.; Sci Adv, 5:eaav1882-eaav1882, 2019; PubMed: 30613781; DOI: 10.1126/sciadv.aav1882

Experimental method

X-RAY DIFFRACTION (3.25 Å)