6BI8

X-ray structure of MERS coronavirus papain-like protease in complex with human ISG15

Summary for 6BI8

Entry DOI	10.2210/pdb6bi8/pdb
Descriptor	ORF1a, Ubiquitin-like protein ISG15, TRIETHYLENE GLYCOL, ... (9 entities in total)
Functional Keywords	complex, signaling protein, deisgylase, hydrolase, hydrolase-substrate complex, hydrolase/substrate
Biological source	Human betacoronavirus 2c EMC/2012 More
Total number of polymer chains	4
Total formula weight	93570.69
Authors	Clasman, J.C.,Mesecar, A.D. (deposition date: 2017-11-01, release date: 2018-11-07, Last modification date: 2023-10-04)
Primary citation	Clasman, J.R.,Everett, R.K.,Srinivasan, K.,Mesecar, A.D. Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease. Antiviral Res., 174:104661-104661, 2020 Cited by PubMed: 31765674 DOI: 10.1016/j.antiviral.2019.104661 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.291 Å)

Structure validation