6BI8
X-ray structure of MERS coronavirus papain-like protease in complex with human ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ORF1a | polymer | 259 | 28883.5 | 2 | UniProt (K4LC41) Pfam (PF08715) UniProt (by SIFTS) (K0BWD0) | Human betacoronavirus 2c EMC/2012 | |
| 2 | C, D (C, D) | Ubiquitin-like protein ISG15 | polymer | 156 | 17090.6 | 2 | UniProt (P05161) Pfam (PF00240) | Homo sapiens (Human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 3 | E, J, K, T (A, B, C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 4 | F, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G, H, M, N, O (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | I, S (A, B) | prop-2-en-1-amine | non-polymer | 57.1 | 2 | Chemie (AYE) | |||
| 7 | P (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 8 | Q, R (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 1544 - 1801 (UniProt: K4LC41)
C, D: 1 - 156 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Asn 1543 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 78 | Cys 78 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91948.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1622.4 | |
| All* | Total formula weight | 93570.7 |
