Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BI8

X-ray structure of MERS coronavirus papain-like protease in complex with human ISG15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007229	biological_process	integrin-mediated signaling pathway
C	0009615	biological_process	response to virus
C	0009617	biological_process	response to bacterium
C	0016567	biological_process	protein ubiquitination
C	0019941	biological_process	modification-dependent protein catabolic process
C	0030501	biological_process	positive regulation of bone mineralization
C	0031386	molecular_function	protein tag activity
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032020	biological_process	ISG15-protein conjugation
C	0032461	biological_process	positive regulation of protein oligomerization
C	0032649	biological_process	regulation of type II interferon production
C	0032728	biological_process	positive regulation of interferon-beta production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0034340	biological_process	response to type I interferon
C	0042742	biological_process	defense response to bacterium
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0051607	biological_process	defense response to virus
C	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
C	0070585	biological_process	protein localization to mitochondrion
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007229	biological_process	integrin-mediated signaling pathway
D	0009615	biological_process	response to virus
D	0009617	biological_process	response to bacterium
D	0016567	biological_process	protein ubiquitination
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030501	biological_process	positive regulation of bone mineralization
D	0031386	molecular_function	protein tag activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032020	biological_process	ISG15-protein conjugation
D	0032461	biological_process	positive regulation of protein oligomerization
D	0032649	biological_process	regulation of type II interferon production
D	0032728	biological_process	positive regulation of interferon-beta production
D	0032729	biological_process	positive regulation of type II interferon production
D	0032733	biological_process	positive regulation of interleukin-10 production
D	0034340	biological_process	response to type I interferon
D	0042742	biological_process	defense response to bacterium
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0051607	biological_process	defense response to virus
D	0060339	biological_process	negative regulation of type I interferon-mediated signaling pathway
D	0070585	biological_process	protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PGE A 1901

Chain	Residue
A	HIS1562
A	ARG1563
A	SER1566
A	CYS1639
A	THR1640
A	HOH2083
D	ASP119
D	ASP120

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1902

Chain	Residue
A	CYS1675
A	CYS1707
A	CYS1709
A	CYS1672

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 1903

Chain	Residue
A	TYR1690
A	GLY1692
A	HOH2006

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 1904

Chain	Residue
A	HIS1652
A	CYS1689
C	PRO130
C	HOH315

site_id	AC5
Number of Residues	3
Details	binding site for residue PGE B 1901

Chain	Residue
B	GLU1754
B	HOH2117
D	ARG153

site_id	AC6
Number of Residues	5
Details	binding site for residue PGE B 1902

Chain	Residue
A	GLY1623
A	ASP1625
B	GLU1545
B	HOH2090
B	HOH2092

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 1903

Chain	Residue
B	CYS1672
B	CYS1675
B	CYS1707
B	CYS1709

site_id	AC8
Number of Residues	2
Details	binding site for residue GOL B 1904

Chain	Residue
B	ASP1557
B	ASN1638

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL B 1905

Chain	Residue
B	HIS1652
B	HOH2110
D	PRO130
D	HOH316

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL B 1906

Chain	Residue
B	TRP1668
B	GLU1670
B	VAL1680
B	LEU1682
B	ARG1715
D	GLU127
D	LYS129

site_id	AD2
Number of Residues	6
Details	binding site for residue CIT B 1907

Chain	Residue
A	GLU1545
B	GLY1623
B	GLY1624
B	HOH2070
B	HOH2089
B	HOH2113

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO B 1908

Chain	Residue
B	VAL1556
B	ASP1557
B	ARG1563
B	ALA1635
B	ASN1638

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO B 1909

Chain	Residue
B	TYR1690
B	GLY1692
B	MET1703

site_id	AD5
Number of Residues	6
Details	binding site for residue PGE C 201

Chain	Residue
A	THR1755
A	ALA1756
A	VAL1757
C	LEU121
C	ARG153
C	ARG155

site_id	AD6
Number of Residues	9
Details	binding site for Di-peptide AYE A 1905 and GLY C 156

Chain	Residue
A	LEU1587
A	ASN1590
A	CYS1592
A	TYR1593
A	PRO1644
A	ASP1645
A	GLY1758
A	HIS1759
C	ARG155

site_id	AD7
Number of Residues	9
Details	binding site for Di-peptide AYE B 1910 and GLY D 156

Chain	Residue
B	LEU1587
B	ASN1590
B	CYS1592
B	TYR1593
B	PRO1644
B	ASP1645
B	GLY1758
B	HIS1759
D	ARG155

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interacts with activating enzyme => ECO:0000250

Chain	Residue	Details
C	ARG153
D	ARG153

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine; alternate => ECO:0000269\|PubMed:18606809

Chain	Residue	Details
C	SER78
D	SER78

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)