6B8B

E. coli LptB in complex with ADP and a novobiocin derivative

Summary for 6B8B

• Entry DOI: 10.2210/pdb6b8b/pdb
• Related: 6B89
• Descriptor: Lipopolysaccharide export system ATP-binding protein LptB, MAGNESIUM ION, (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-ben zopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide, ... (5 entities in total)
• Functional Keywords: lptb, abc transporter, lps transport, lipid transport, lipid transport-activator complex, lipid transport/activator
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 1
• Total formula weight: 28978.90

Authors

Mandler, M.D.,Owens, T.W.,Lazarus, M.B.,May, J.M.,Kahne, D.K. (deposition date: 2017-10-06, release date: 2017-12-06, Last modification date: 2023-10-04)

• Primary citation: May, J.M.,Owens, T.W.,Mandler, M.D.,Simpson, B.W.,Lazarus, M.B.,Sherman, D.J.,Davis, R.M.,Okuda, S.,Massefski, W.,Ruiz, N.,Kahne, D.; The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.; J. Am. Chem. Soc., 139:17221-17224, 2017; PubMed: 29135241; DOI: 10.1021/jacs.7b07736

Experimental method

X-RAY DIFFRACTION (1.95 Å)