6B73

Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor

6B73 の概要

• エントリーDOI: 10.2210/pdb6b73/pdb
• 分子名称: Soluble cytochrome b562, kappa-type opioid receptor, Nanobody, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, ... (5 entities in total)
• 機能のキーワード: gpcr, opioid receptor, addiction, active state, nanobody, structure-function, morphinan, lcp, membrane protein, membrane protein-agonist complex, membrane protein/agonist
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126051.35

構造登録者

Che, T.,Majumdar, S.,Zaidi, S.A.,Kormos, C.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, I.F.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L. (登録日: 2017-10-03, 公開日: 2018-01-17, 最終更新日: 2023-10-04)

• 主引用文献: Che, T.,Majumdar, S.,Zaidi, S.A.,Ondachi, P.,McCorvy, J.D.,Wang, S.,Mosier, P.D.,Uprety, R.,Vardy, E.,Krumm, B.E.,Han, G.W.,Lee, M.Y.,Pardon, E.,Steyaert, J.,Huang, X.P.,Strachan, R.T.,Tribo, A.R.,Pasternak, G.W.,Carroll, F.I.,Stevens, R.C.,Cherezov, V.,Katritch, V.,Wacker, D.,Roth, B.L.; Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.; Cell, 172:55-67.e15, 2018; PubMed: 29307491; DOI: 10.1016/j.cell.2017.12.011

実験手法

X-RAY DIFFRACTION (3.1 Å)