6B0F

ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH LSZ102

Summary for 6B0F

• Entry DOI: 10.2210/pdb6b0f/pdb
• Descriptor: Estrogen receptor, LSZ102, GLYCEROL, ... (4 entities in total)
• Functional Keywords: nuclear receptor, hormone receptor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 59012.96

Authors

Kirby, C.A.,Baird, J. (deposition date: 2017-09-14, release date: 2018-04-04, Last modification date: 2024-04-03)

• Primary citation: Tria, G.S.,Abrams, T.,Baird, J.,Burks, H.E.,Firestone, B.,Gaither, L.A.,Hamann, L.G.,He, G.,Kirby, C.A.,Kim, S.,Lombardo, F.,Macchi, K.J.,McDonnell, D.P.,Mishina, Y.,Norris, J.D.,Nunez, J.,Springer, C.,Sun, Y.,Thomsen, N.M.,Wang, C.,Wang, J.,Yu, B.,Tiong-Yip, C.L.,Peukert, S.; Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.; J. Med. Chem., 61:2837-2864, 2018; PubMed: 29562737; DOI: 10.1021/acs.jmedchem.7b01682

Experimental method

X-RAY DIFFRACTION (2.86 Å)