6ARJ

Crystal structure of CARM1 with EPZ022302 and SAH

Summary for 6ARJ

Entry DOI	10.2210/pdb6arj/pdb
Descriptor	Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE, methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, protein arginine methyltransferase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q86X55
Total number of polymer chains	4
Total formula weight	162927.04
Authors	Boriack-Sjodin, P.A.,Jin, L. (deposition date: 2017-08-22, release date: 2018-02-07, Last modification date: 2024-03-13)
Primary citation	Drew, A.E.,Moradei, O.,Jacques, S.L.,Rioux, N.,Boriack-Sjodin, A.P.,Allain, C.,Scott, M.P.,Jin, L.,Raimondi, A.,Handler, J.L.,Ott, H.M.,Kruger, R.G.,McCabe, M.T.,Sneeringer, C.,Riera, T.,Shapiro, G.,Waters, N.J.,Mitchell, L.H.,Duncan, K.W.,Moyer, M.P.,Copeland, R.A.,Smith, J.,Chesworth, R.,Ribich, S.A. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep, 7:17993-17993, 2017 Cited by PubMed: 29269946 DOI: 10.1038/s41598-017-18446-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation