6ARJ
Crystal structure of CARM1 with EPZ022302 and SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-arginine methyltransferase CARM1 | polymer | 349 | 39623.1 | 4 | UniProt (Q86X55) Pfam (PF06325) Pfam (PF22528) | Homo sapiens (Human) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | E, H, K, O (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | F, I, L, P (A, B, C, D) | methyl 2-[2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate | non-polymer | 585.1 | 4 | Chemie (BW4) | |||
| 4 | G, J, M, Q, R (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | N (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 850 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 134 - 479 (UniProt: Q86X55)
| PDB | External Database | Details |
|---|---|---|
| Ser 131 | - | expression tag |
| Ile 132 | - | expression tag |
| Ala 133 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 158492.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4434.6 | |
| All* | Total formula weight | 162927.0 |
