6ARJ
Crystal structure of CARM1 with EPZ022302 and SAH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
A | 0018216 | biological_process | peptidyl-arginine methylation |
B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
B | 0018216 | biological_process | peptidyl-arginine methylation |
C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
C | 0018216 | biological_process | peptidyl-arginine methylation |
D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue SAH A 501 |
Chain | Residue |
A | TYR149 |
A | LEU198 |
A | GLU214 |
A | ALA215 |
A | GLY240 |
A | LYS241 |
A | VAL242 |
A | GLU243 |
A | GLU257 |
A | MET268 |
A | SER271 |
A | PHE150 |
A | BW4502 |
A | HOH645 |
A | HOH656 |
A | HOH665 |
A | HOH671 |
A | TYR153 |
A | GLN159 |
A | MET162 |
A | ARG168 |
A | GLY192 |
A | CYS193 |
A | ILE197 |
site_id | AC2 |
Number of Residues | 17 |
Details | binding site for residue BW4 A 502 |
Chain | Residue |
A | TYR153 |
A | MET162 |
A | GLU257 |
A | MET259 |
A | TYR261 |
A | ASN265 |
A | GLU266 |
A | MET268 |
A | HIS414 |
A | TRP415 |
A | LYS470 |
A | PHE474 |
A | THR477 |
A | SAH501 |
A | HOH785 |
B | BW4502 |
B | HOH606 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | ASP392 |
A | TRP403 |
A | HOH673 |
site_id | AC4 |
Number of Residues | 25 |
Details | binding site for residue SAH B 501 |
Chain | Residue |
B | TYR149 |
B | PHE150 |
B | TYR153 |
B | GLN159 |
B | MET162 |
B | ARG168 |
B | GLY192 |
B | CYS193 |
B | GLY194 |
B | ILE197 |
B | LEU198 |
B | GLU214 |
B | ALA215 |
B | GLY240 |
B | LYS241 |
B | VAL242 |
B | GLU243 |
B | GLU257 |
B | MET268 |
B | SER271 |
B | BW4502 |
B | HOH625 |
B | HOH660 |
B | HOH678 |
B | HOH681 |
site_id | AC5 |
Number of Residues | 17 |
Details | binding site for residue BW4 B 502 |
Chain | Residue |
A | BW4502 |
B | TYR153 |
B | MET162 |
B | GLU257 |
B | MET259 |
B | TYR261 |
B | ASN265 |
B | GLU266 |
B | MET268 |
B | HIS414 |
B | TRP415 |
B | LYS470 |
B | PHE474 |
B | SAH501 |
B | HOH606 |
B | HOH741 |
B | HOH794 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | SER405 |
B | HOH643 |
site_id | AC7 |
Number of Residues | 24 |
Details | binding site for residue SAH C 501 |
Chain | Residue |
C | GLU214 |
C | ALA215 |
C | GLY240 |
C | LYS241 |
C | VAL242 |
C | GLU243 |
C | MET268 |
C | SER271 |
C | BW4502 |
C | HOH622 |
C | HOH641 |
C | HOH645 |
C | HOH656 |
C | TYR149 |
C | PHE150 |
C | TYR153 |
C | GLN159 |
C | MET162 |
C | ARG168 |
C | GLY192 |
C | CYS193 |
C | GLY194 |
C | ILE197 |
C | LEU198 |
site_id | AC8 |
Number of Residues | 19 |
Details | binding site for residue BW4 C 502 |
Chain | Residue |
C | PHE152 |
C | TYR153 |
C | MET162 |
C | GLU257 |
C | PRO258 |
C | MET259 |
C | TYR261 |
C | ASN265 |
C | GLU266 |
C | MET268 |
C | HIS414 |
C | TRP415 |
C | LYS470 |
C | PHE474 |
C | THR477 |
C | SAH501 |
C | HOH701 |
C | HOH749 |
D | BW4502 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue GOL C 503 |
Chain | Residue |
C | ASP392 |
C | TRP403 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue SO4 C 504 |
Chain | Residue |
C | LYS351 |
C | SER352 |
C | HOH639 |
C | HOH695 |
site_id | AD2 |
Number of Residues | 25 |
Details | binding site for residue SAH D 501 |
Chain | Residue |
D | TYR149 |
D | PHE150 |
D | TYR153 |
D | GLN159 |
D | MET162 |
D | ARG168 |
D | GLY192 |
D | CYS193 |
D | GLY194 |
D | ILE197 |
D | LEU198 |
D | GLU214 |
D | ALA215 |
D | GLY240 |
D | LYS241 |
D | VAL242 |
D | GLU243 |
D | GLU257 |
D | MET268 |
D | SER271 |
D | BW4502 |
D | HOH615 |
D | HOH623 |
D | HOH668 |
D | HOH696 |
site_id | AD3 |
Number of Residues | 19 |
Details | binding site for residue BW4 D 502 |
Chain | Residue |
C | BW4502 |
D | PHE152 |
D | TYR153 |
D | MET162 |
D | GLU257 |
D | PRO258 |
D | MET259 |
D | TYR261 |
D | ASN265 |
D | GLU266 |
D | MET268 |
D | HIS414 |
D | TRP415 |
D | LYS470 |
D | PHE474 |
D | TYR476 |
D | SAH501 |
D | HOH728 |
D | HOH736 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue GOL D 503 |
Chain | Residue |
D | ASP392 |
D | TRP403 |
D | SER405 |
D | HOH691 |
D | HOH729 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
Chain | Residue | Details |
A | GLN159 | |
B | GLU214 | |
B | GLU243 | |
B | SER271 | |
C | GLN159 | |
C | ARG168 | |
C | GLY192 | |
C | GLU214 | |
C | GLU243 | |
C | SER271 | |
D | GLN159 | |
A | ARG168 | |
D | ARG168 | |
D | GLY192 | |
D | GLU214 | |
D | GLU243 | |
D | SER271 | |
A | GLY192 | |
A | GLU214 | |
A | GLU243 | |
A | SER271 | |
B | GLN159 | |
B | ARG168 | |
B | GLY192 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
Chain | Residue | Details |
A | SER216 | |
B | SER216 | |
C | SER216 | |
D | SER216 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
Chain | Residue | Details |
A | LYS227 | |
B | LYS227 | |
C | LYS227 | |
D | LYS227 |