6APV
Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid
Summary for 6APV
Entry DOI | 10.2210/pdb6apv/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | trypanosoma brucei, purine salvage, acyclic nucleoside biphosphonate, transferase |
Biological source | Trypanosoma brucei brucei |
Cellular location | Cytoplasm: Q07010 |
Total number of polymer chains | 4 |
Total formula weight | 99259.10 |
Authors | Teran, D.,Guddat, L.W. (deposition date: 2017-08-18, release date: 2018-03-14, Last modification date: 2023-10-04) |
Primary citation | Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.993 Å) |
Structure validation
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