6APV

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid

Summary for 6APV

Entry DOI	10.2210/pdb6apv/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	trypanosoma brucei, purine salvage, acyclic nucleoside biphosphonate, transferase
Biological source	Trypanosoma brucei brucei
Cellular location	Cytoplasm: Q07010
Total number of polymer chains	4
Total formula weight	99259.10
Authors	Teran, D.,Guddat, L.W. (deposition date: 2017-08-18, release date: 2018-03-14, Last modification date: 2023-10-04)
Primary citation	Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567 DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.993 Å)

Structure validation