6APV
Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| A | 0097014 | cellular_component | ciliary plasm |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0097014 | cellular_component | ciliary plasm |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006178 | biological_process | guanine salvage |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0020015 | cellular_component | glycosome |
| C | 0031981 | cellular_component | nuclear lumen |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0097014 | cellular_component | ciliary plasm |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006178 | biological_process | guanine salvage |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0020015 | cellular_component | glycosome |
| D | 0031981 | cellular_component | nuclear lumen |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0097014 | cellular_component | ciliary plasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue 3L4 A 301 |
| Chain | Residue |
| A | LYS54 |
| A | LYS145 |
| A | VAL165 |
| A | PHE166 |
| A | VAL167 |
| A | LEU172 |
| A | ASP173 |
| A | ARG179 |
| A | MG302 |
| A | MG303 |
| A | HOH406 |
| A | GLY55 |
| A | HOH409 |
| A | HOH416 |
| A | HOH425 |
| A | HOH432 |
| A | HOH437 |
| A | HOH443 |
| A | HOH491 |
| A | GLU113 |
| A | ILE115 |
| A | ASP117 |
| A | THR118 |
| A | ALA119 |
| A | LEU120 |
| A | THR121 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP173 |
| A | 3L4301 |
| A | HOH406 |
| A | HOH443 |
| A | HOH474 |
| A | HOH491 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | VAL52 |
| A | GLY55 |
| A | SER56 |
| A | GLU113 |
| A | ASP114 |
| A | 3L4301 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 304 |
| Chain | Residue |
| A | ARG182 |
| B | ARG25 |
| B | ILE66 |
| B | PEG304 |
| B | HOH468 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | binding site for residue 3L4 B 301 |
| Chain | Residue |
| B | LYS54 |
| B | GLY55 |
| B | GLU113 |
| B | ILE115 |
| B | ASP117 |
| B | THR118 |
| B | ALA119 |
| B | LEU120 |
| B | THR121 |
| B | LYS145 |
| B | VAL165 |
| B | PHE166 |
| B | VAL167 |
| B | LEU172 |
| B | ASP173 |
| B | ARG179 |
| B | MG302 |
| B | MG303 |
| B | HOH402 |
| B | HOH410 |
| B | HOH413 |
| B | HOH417 |
| B | HOH418 |
| B | HOH419 |
| B | HOH435 |
| B | HOH502 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | ASP173 |
| B | 3L4301 |
| B | HOH418 |
| B | HOH419 |
| B | HOH502 |
| B | HOH504 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | VAL52 |
| B | GLY55 |
| B | SER56 |
| B | GLU113 |
| B | ASP114 |
| B | 3L4301 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 304 |
| Chain | Residue |
| A | HIS21 |
| A | ARG65 |
| A | ILE66 |
| A | PEG304 |
| B | ARG182 |
| B | HOH456 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | binding site for residue 3L4 C 301 |
| Chain | Residue |
| C | VAL167 |
| C | ASP173 |
| C | ARG179 |
| C | MG302 |
| C | MG303 |
| C | HOH406 |
| C | HOH413 |
| C | HOH421 |
| C | HOH424 |
| C | HOH442 |
| C | HOH492 |
| C | HOH541 |
| C | LYS54 |
| C | GLY55 |
| C | GLU113 |
| C | ILE115 |
| C | ASP117 |
| C | THR118 |
| C | ALA119 |
| C | LEU120 |
| C | THR121 |
| C | LYS145 |
| C | VAL165 |
| C | PHE166 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | ASP173 |
| C | 3L4301 |
| C | HOH406 |
| C | HOH414 |
| C | HOH462 |
| C | HOH492 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 303 |
| Chain | Residue |
| C | VAL52 |
| C | GLY55 |
| C | SER56 |
| C | GLU113 |
| C | ASP114 |
| C | 3L4301 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG C 304 |
| Chain | Residue |
| C | GLU17 |
| C | HIS21 |
| C | ASP62 |
| C | ARG182 |
| C | HOH500 |
| site_id | AD4 |
| Number of Residues | 25 |
| Details | binding site for residue 3L4 D 301 |
| Chain | Residue |
| D | LYS54 |
| D | GLY55 |
| D | ILE115 |
| D | ASP117 |
| D | THR118 |
| D | ALA119 |
| D | LEU120 |
| D | THR121 |
| D | LYS145 |
| D | VAL165 |
| D | PHE166 |
| D | VAL167 |
| D | LEU172 |
| D | ASP173 |
| D | ARG179 |
| D | MG302 |
| D | MG303 |
| D | HOH405 |
| D | HOH406 |
| D | HOH407 |
| D | HOH415 |
| D | HOH425 |
| D | HOH467 |
| D | HOH477 |
| D | HOH490 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| D | ASP173 |
| D | 3L4301 |
| D | HOH425 |
| D | HOH443 |
| D | HOH477 |
| D | HOH490 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 303 |
| Chain | Residue |
| D | VAL52 |
| D | GLY55 |
| D | SER56 |
| D | GLU113 |
| D | ASP114 |
| D | 3L4301 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PEG D 304 |
| Chain | Residue |
| D | GLU17 |
| D | HIS21 |
| D | ARG182 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLVLEDILDTAlT |
| Chain | Residue | Details |
| A | VAL109-THR121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
