6APV

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine phosphoribosyltransferase	polymer	216	24221.8	4	UniProt (Q07010) Pfam (PF00156)	Trypanosoma brucei brucei	HGPRTase
2	E, I, M, Q (A, B, C, D)	[(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid	non-polymer		438.3	4	Chemie (3L4)
3	F, G, J, K, N... (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
4	H, L, P, T (A, B, C, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
5	U, V, W, X (A, B, C, D)	water	water		18.0	574	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 210 (UniProt: Q07010)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96887.1
Non-Polymers*	Number of molecules	16
	Total formula weight	2372.0
All*	Total formula weight	99259.1

*Water molecules are not included.