6X1B

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with the Product Nucleotide GpU.

Summary for 6X1B

• Entry DOI: 10.2210/pdb6x1b/pdb
• Related: 6VWW 6W01 6WLC 6WXC
• Descriptor: Uridylate-specific endoribonuclease, DNA (5'-R(*GP*U)-3'), PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: sars corona virus 2, endoribonuclease, covid-19, structural genomics, center for structural genomics of infectious diseases, csgid, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 4
• Total formula weight: 84903.45

Authors

Kim, Y.,Maltseva, N.,Jedrzejczak, R.,Welk, L.,Endres, M.,Chang, C.,Michalska, K.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-05-18, release date: 2020-05-27, Last modification date: 2023-10-18)

• Primary citation: Kim, Y.,Wower, J.,Maltseva, N.,Chang, C.,Jedrzejczak, R.,Wilamowski, M.,Kang, S.,Nicolaescu, V.,Randall, G.,Michalska, K.,Joachimiak, A.; Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.; Commun Biol, 4:193-193, 2021; PubMed: 33564093; DOI: 10.1038/s42003-021-01735-9

Experimental method

X-RAY DIFFRACTION (1.97 Å)