6X1B
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with the Product Nucleotide GpU.
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue PO4 A 401 |
Chain | Residue |
A | HIS235 |
A | GLY248 |
A | HIS250 |
A | LYS290 |
A | THR341 |
A | HOH560 |
A | HOH567 |
D | G401 |
D | U402 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue EDO B 501 |
Chain | Residue |
A | LYS320 |
A | THR322 |
A | GLU327 |
B | VAL149 |
B | LYS150 |
B | GLY151 |
B | LEU152 |
B | HOH745 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue EDO B 502 |
Chain | Residue |
B | THR113 |
B | GLU114 |
B | HOH678 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
B | SER244 |
B | GLN245 |
B | SER289 |
B | HOH610 |
B | HOH615 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue PO4 B 504 |
Chain | Residue |
B | HIS235 |
B | GLY248 |
B | HIS250 |
B | LYS290 |
B | THR341 |
B | TYR343 |
F | G401 |
F | U402 |
F | HOH502 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | HIS235 | |
B | HIS235 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | HIS250 | |
B | HIS250 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | THR341 | |
B | THR341 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | SER294 | |
B | SER294 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
Chain | Residue | Details |
A | GLN347 | |
B | GLN347 |