6WXC

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with potential repurposing drug Tipiracil

Summary for 6WXC

Entry DOI	10.2210/pdb6wxc/pdb
Related	6VWW 6W01 6WLC
Descriptor	Uridylate-specific endoribonuclease, 5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	sars corona virus 2, endoribonuclease, refurbishing drug, covid-19, structural genomics, center for structural genomics of infectious diseases, csgid, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	2
Total formula weight	84732.45
Authors	Kim, Y.,Maltseva, N.,Jedrzejczak, R.,Welk, L.,Endres, M.,Chang, C.,Michalska, K.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-05-10, release date: 2020-05-20, Last modification date: 2023-10-18)
Primary citation	Kim, Y.,Wower, J.,Maltseva, N.,Chang, C.,Jedrzejczak, R.,Wilamowski, M.,Kang, S.,Nicolaescu, V.,Randall, G.,Michalska, K.,Joachimiak, A. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol, 4:193-193, 2021 Cited by PubMed: 33564093 DOI: 10.1038/s42003-021-01735-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation