6X0P

Ash1L SET domain Q2265A mutant in complex with AS-5

Summary for 6X0P

Entry DOI	10.2210/pdb6x0p/pdb
Descriptor	Histone-lysine N-methyltransferase ASH1L, 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, ZINC ION, ... (5 entities in total)
Functional Keywords	methyltransferase, complex, protein binding, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	107518.23
Authors	Rogawski, D.S.,Li, H.,Borkin, D.,Cierpicki, T.,Grembecka, J. (deposition date: 2020-05-17, release date: 2021-04-07, Last modification date: 2023-10-18)
Primary citation	Rogawski, D.S.,Deng, J.,Li, H.,Miao, H.,Borkin, D.,Purohit, T.,Song, J.,Chase, J.,Li, S.,Ndoj, J.,Klossowski, S.,Kim, E.,Mao, F.,Zhou, B.,Ropa, J.,Krotoska, M.Z.,Jin, Z.,Ernst, P.,Feng, X.,Huang, G.,Nishioka, K.,Kelly, S.,He, M.,Wen, B.,Sun, D.,Muntean, A.,Dou, Y.,Maillard, I.,Cierpicki, T.,Grembecka, J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12:2792-2792, 2021 Cited by PubMed: 33990599 DOI: 10.1038/s41467-021-23152-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation