6WNA
Next generation monomeric IgG4 Fc
Summary for 6WNA
Entry DOI | 10.2210/pdb6wna/pdb |
Descriptor | IgG receptor FcRn large subunit p51, Beta-2-microglobulin, Immunoglobulin heavy constant gamma 4, ... (5 entities in total) |
Functional Keywords | antibody constant region, fragment crystallizable, mutated, immune system, neonatal receptor interaction, half-life |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 66595.43 |
Authors | Oganesyan, V.Y.,Shan, L.,van Dyk, N.,Dall'Acqua, W.F. (deposition date: 2020-04-22, release date: 2021-09-15, Last modification date: 2023-10-18) |
Primary citation | Shan, L.,Dyk, N.V.,Haskins, N.,Cook, K.M.,Rosenthal, K.L.,Mazor, R.,Dragulin-Otto, S.,Jiang, Y.,Wu, H.,Dall'Acqua, W.F.,Borrok, M.J.,Damschroder, M.M.,Oganesyan, V. In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4:1048-1048, 2021 Cited by PubMed: 34497355DOI: 10.1038/s42003-021-02565-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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