6UZK
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6
Summary for 6UZK
Entry DOI | 10.2210/pdb6uzk/pdb |
Related | 6OQ3 6OQ4 |
Descriptor | Krev interaction trapped protein 1, Ras-related protein Rap-1b, 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde, ... (6 entities in total) |
Functional Keywords | complex, small molecules, gtpase, krit1, cell adhesion |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 57141.56 |
Authors | Gingras, A.R. (deposition date: 2019-11-15, release date: 2020-11-18, Last modification date: 2023-10-11) |
Primary citation | Lopez-Ramirez, M.A.,McCurdy, S.,Li, W.,Haynes, M.K.,Hale, P.,Francisco, K.,Oukoloff, K.,Bautista, M.,Choi, C.H.J.,Sun, H.,Gongol, B.,Shyy, J.Y.,Ballatore, C.,Sklar, L.A.,Gingras, A.R. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadv, 3:334-355, 2021 Cited by PubMed: 33977234DOI: 10.1096/fba.2020-00141 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.924 Å) |
Structure validation
Download full validation report